This is the source code for three compuational models used for generating connectivity and swimming functionality of spinal cord neurons in the Xenopus tadpoles using biological data.
- The first model uses biological data to reconstruct a complete map of synaptic interactions between spinal neuron (anatomical connectome), in the folder "anatomical model".
- The second model generalizes the anatomical model by averaging a number of anatomical connectomes and thus generating a matrix of connection probabilities between the neurons, in the folder "probabilistic model".
- The third model uses the previous two to generate connectivity between neurons and simulates the dynamics of this circuit using Neuron (tested with version 7.3), in the folder "functional model".
A README file contained in the folder of each piece of the model explains how to run the simulations and give a description of the models. For a more complete description of these models have a look at (please cite, if you are using this model):
- Borisyuk et al., 2014, PLoS One
- Roberts et al., 2014, Journal of Neuroscience
For any problem contact me.
Author: Andrea Ferrario, University of Plymouth Last Update: 21/1/2018 Email: andrea.ferrario@plymouth.ac.uk